Maspin influences response to doxorubicin by changing the tumor microenvironment organization
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چکیده
منابع مشابه
Maspin influences response to doxorubicin by changing the tumor microenvironment organization.
Altered degradation and deposition of extracellular matrix are hallmarks of tumor progression and response to therapy. From a microarray supervised analysis on a dataset of chemotherapy-treated breast carcinoma patients, maspin, a member of the serpin protease inhibitor family, has been the foremost variable identified in non-responsive versus responsive tumors. Accordingly, in a series of 52 h...
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Despite the promising clinical outcome, the primary challenge of the curative cancer immunotherapy is to overcome the dichotomy of the immune response: tumor-evoked immunostimulatory versus tumor-induced immunosuppressive. The goal needs to be two-fold, to re-establish sustainable antitumor-cancer immunity and to eliminate immunosuppression. The successful elimination of cancer cells by immunos...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2013
ISSN: 0020-7136
DOI: 10.1002/ijc.28608